The only real irk I have with the bog standard RPi design-wise is the connections being spread across two sides which makes a less obtrusive use just that bit more complicated.
Generally I have managed to get round that via modifications to the circuit board, component layout and related case modifications.
Quite easy to do with the RPi provided you are OK with cutting tin and surface mount soldering
Once you've crossed that bridge a much more amenable design is possible.
When I had a Pi and Khadas Tone board I stuck the lot inside a eddy ardo case