There's a new Regen which includes galvanic isolation; hence the higher price.
Sorry to have mislead... I should have said "new ISO REGEN" which is on the order of $325 and which includes galvanic isolation, a redesign of the original REGEN which is still available for $175.
Based on comments in this thread by those who I have come to know thru their posts, I have no doubt that John's DETOX will surpass the REGEN in both improved sound quality as well as construction based on number of machine screws if nothing else. I have less confidence in the performance of the ISO REGEN if only based on my personal experience.
C'mon DETOX!