My four penneth...
All audio is a waveform. Digital audio is a sampled waveform, regardless of bit rate etc so always loses a certain something. (This is why analogue vinyl is best, though some here will disagree) With speakers tweeters are more important than cones as the cones are for longer and thus more imprecise waveforms. We know a tweeter can sound sweet or harsh, like you can tell someone speaking with false teeth, there is a sibilance to the sound. I'm digressing.
Speakers are the most important. Amplifiers amplify. Source should be analogue.
But my real point is that room acoustics do make a difference. Try having a conversation in a restaurant with music and lots of chatter, its hard. Turn off the music...better. Cut the chatter...better still. A smaller room with many non reflective surfaces like curtains, books on shelves etc and your almost in a sound chamber...there is your speaker sweet spot. That's why a pair of hand made speakers will show a good sound...but I will bet a pair of other speakers would too. Which other ? Classics like LS35a, Tannoys, Epos....