I built my active kitchen speakers using a MiniDSP 2x4HD as my preamp/x-over, and set it up using a umik-1 and room EQW.
My main 'worry' in your proposed setup is that you may 'undo' some of the MDAC 'magic' by passing the signal, first through a preamp (although I do this myself, for another reason - I don't believe you can 'enhance' the sound by going through another stage) and then re-digitising your signal to process it via the miniDSP.
That said, it's all about reading all the (excellent) instructions and taking a methodical approach. I was building a two way small speaker that was intended for a specific location. The first thing I did was to take some near field measurements of the bass unit in the cabinet, to determine where I should set the crossover frequency, and to assess the response in the near field. I then applied a correction curve that gave me the correct crossover frequency, and a correction for the inevitable bass rolloff, as I don't need high volumes, so I can pump the bass up. I then introduced the tweeters, which didn't need anything other than the crossover frequency setting. I them moved the speakers into the (decidedly sub optimal) position, and then I did a full frequency sweep to find out what the frequency response was in situ. I then tweaked that correction, so as to correct peaks without over driving nulls which is pointless and problematic. Net result is I have some Kan sized speakers that are flat to 50Hz, sound amazing, voiced for Radio4 speech mainly, but don't go loud.