I bought a 180 25 years ago when they were newly introduced and was very happy with it. About 15 years later I got a pair of SBLs and, because everyone said you should, I bought a used 250 of a similar vintage to the 180 and it sounded exactly the same. When you consider that they both contained exactly the same NAPA amplifier boards of the same issue (6 I think) that's not too surprising.
Last year I bought a pair of Shahinian Obelisks and the 250 didn't produce any treble from the speakers. A lengthy trawl of the internet revealed the surprising news that the power supply regulator boards in the 250 didn't like delivering current into low impedances at high frequencies and the 4 tweeters in the obelisks gave a 2 ohm impedance throughout the treble range, a 180 was suggested as a better choice. I dragged my old 180 out of retirement and it was much better than the 250 with my "new" speakers!
I subsequently sold the 250 and bought another 180 with a view to fitting Avondale modules in place of the Naim boards but first tried the 180, one of the last ones made (late 2001), as received.
It sounded awful! Totally lacking dynamics and PRAT (but possibly more relaxed easy going?).
A check inside showed the output stage bias adjustment to be very low (and equal on both channels), and after adjusting both channels to the recommended 36 - 38 ma it sounded great, just the same as my original 180.
I speculated that my original 180, newly introduced at the time, had been set up for optimum performance whilst the later one, just about to be replaced by the new NAP200, might possibly have been set up so as not to outshine the upcoming new model!
Once fitted with the Avondale NCC200 boards the 180 (newer one but it doesn't matter) there was noticeably more fine detail and deeper bass.
With the NCC200s replaced with LesW's new NCC220s it was a further improvement.
My conclusion was that the (correctly set up)180 was just as good as the 250 but a 180 fitted with Avondale modules is better than both.
If your speakers are a difficult load then I would think the Avondaled 180 would be the favourite.