In short yes...the data will always get through 'bit perfect' (assuming the correct configuration)
I have an asynchronous MDAC (L2 Toy upgrade) fed by an SBTouch, I can test for 'Bit Perfect' with some test files...I can get bit perfect results via various connections, a cheap USB cable, a more expensive one, then with a USB isolator (iFi USB3)...getting the data bit perfect to your DAC is not difficult IMHO, isolating your DAC from RF interference from a hard wired USB cable is where the benefits have occurred in my system...probably all very DAC dependant