Despite the dismissal of Steve Silberman's tutorial, imo his main argument is central to achieving great sound from a computer. (OK, he does mention right at the end the Audioquest mains filter unit that costs $8,000, but in response to a question from the audience and not as part of a sales pitch.)
Some of his theory may be shaky too, for all I know, but all the improvements I've heard here have been brought about by chipping away at the noise floor. Maybe folk have trouble with the term 'noise' because its normal usage implies an audible addition to the sound, like surface noise on a record, or tape hiss; it's harder to grasp the fact that noise so low that it doesn't register as sound can mask some or all of that tiny percentage of the audio signal that the brain interprets as 'the real thing'.
His views on wireless streaming also make perfect sense to me - if RF contamination is one of the noise contributors you are trying to defeat, why would you re-introduce a radio signal into the process? (Fine if we're talking background music or (maybe) hard rock, but not for 'serious' listening.)
If classical music is your thing (or one of them) I reckon BBC Radio3 is a useful benchmark: a high quality tuner + strong FM signal will sound sweet and detailed and cause no fatigue for hours on end. If your digital music is less enjoyable and less pleasant to listen to for long periods then the system needs to be improved. Equally, if an HD online broadcast doesn't sound significantly more realistic than the FM programme, then your source isn't up to the job.
Another thing Steve mentions is that the isolation/clean-up process is incremental - a single step may be hard to notice on its own, but add them all together and you have a significant improvement in sound. 'Well, he would say that, wouldn't he?' Of course he's in business to sell products to customers, but he strikes me as someone who believes in his products and cares as much about the music as he does about the bottom line.
And I can hardly wait to get my hands on the Detox - many of us are in for a pleasant surprise.